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Cancer encompasses a broad family of more than 100 complex diseases that share the phenomenon of cell populations that undergo uncontrolled division and also have the potential to invade other tissues in the body. Our ability to understand the vast complexity of cancer, much less clinically control it, is only as good as the tools we have available to study it. For materials scientists seeking to understand the challenges and opportunities, the tutorial will provide an overview of two important fields of technology development: modeling systems and analysis tools.
Materials science is a fundamental feature driving progress in both of these critical fields, yet more is required from the materials science community to further advance capabilities on both fronts. For example, new hydrogel materials for 3D cell culture were integrated in microfluidics for modeling tumor angiogenesis. Novel magnetic nanomaterials were exploited for tumor targeting and biomarker detection. Symposium K will highlight groundbreaking advances that span a broad landscape of emerging molecular- and cellular-scale technologies focused on cancer.
Part I of the tutorial discusses the evolution of microsystems for modeling tumor development, progression and metastasis. In particular, descriptions on tumor vascular modeling capturing early stage mechanisms of metastatic potential and characterizing epithelial to mesenchymal transition will provide materials scientists with an understanding of critical events of tumorigenesis, proliferation and progression.
Part II focuses on innovative molecular and cellular detection technologies, especially for cancer diagnosis and monitoring. A broad spectrum of sensor technologies that have been applied towards targeting and tracking molecular markers, circulating tumor cells, and trafficking vesicles used to identify cancer is discussed.
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Pursuit of scientific discovery is the central underpinning concept of modern civilization. The immense investment in government-sponsored research in the U.S. has laid the foundation for national scientific, economic, and military security in the 21st century. However, the doubling of scientific publications every nine years jeopardizes this foundation because it is becoming increasingly difficult to track the vast majority of relevant research, and hence explore and evaluate relevant information.
For scientists to maintain their awareness of relevant scientific work and continue to make advances in fundamental and applied research, original approaches that utilize newly emerging computational methods and machine-learning capabilities to accelerate scientific progress must be developed.
This tutorial presents novel computational analytic methods capable of unlocking the human knowledge that’s been documented and archived in the unstructured text of hundreds of millions of scientific publications to extend scientific discovery beyond human capacity.
The instructors explore pathways for visualizing and comprehending knowledge propagation, evolution, and assessment of scientific research fronts, and methods for quantifying research impact within the scientific community and beyond.
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Maria Tchernycheva reviews the forefront of applied research enabled by nitride (lll-N) semiconductor nanowires. She focuses on nanowire optoelectronic applications such as light emission and photodetection to explain how these nanomaterials have the potential to boost device performance, improve energy efficiency, reduce cost and bring new functionalities. Device fabrication and characterization is described in detail along with recent advances towards flexible nanowire devices.
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