To view this presentation:

  • If you have an MRS account, click the Login button above.
  • New to MRS?  Create a free account here



  0       0

2014 MRS Spring Meeting


W8.06 - Supramolecular Glycopeptide Nanosystems for Chondrogenic Differentiation


Apr 24, 2014 3:45pm ‐ Apr 24, 2014 4:00pm

Description

Interactions between mesenchymal stem cells and extracellular matrix have a regulatory function on differentiation of multipotent stem cells. Cues presented by native matrix can be exploited to design engineered scaffolds to induce in vitro differentiation. Hyaluronic acid is a native component of cartilage and mesenchymal stem cells interact via several cell surface receptors with hyaluronic acid. These interactions play role in cellular signaling and subsequent cartilage tissue development.

Here, first we design multivalent glyconanostructures using high-aspect-ratio self-assembled peptide nanofibers emulating hyaluronic acid function. Then, in vitro chondrogenic differentiation was analyzed on hyaluronic acid mimetic peptide nanofibers. Our results showed that peptide nanofibers induced early chondrogenic differentiation with respect to control groups. This early chondrogenesis was achieved through CD44, a primary receptor for hyaluronic acid, revealed by antibody inhibition assay. These results show that hyaluronic acid mimetic peptide nanofiber system provides a promising platform for stem-cell based cartilage regeneration.

Speaker(s):

You must be logged in and own this session in order to post comments.

Print Certificate
Review Answers
Print Transcript
Completed on: token-completed_on
Review Answers
Please select the appropriate credit type:
/
test_id: 
credits: 
completed on: 
rendered in: 
* - Indicates answer is required.
token-content

token-speaker-name
token-index
token-content
token-index
token-content
token-index
token-content
token-index
token-content
token-index
token-content
token-index
token-content
/
/
token-index
token-content
token-index
token-content