Developed biomaterials and their concept of controlled drug delivery system are proven their excellence in this research. The biomaterial, prepared using hydroxyapatite (HAp), shows a hollow structure with the presence of connections between inner and outer surface to load drug carriers. The poly (lactic-co-glycolic acid) nanoparticles as a drug carrier contain dexamethasone, which is known to cause osteoinduction. Surface of the drug carriers are modified using polyethyleneimine and therefore is able to conjugate to the surface of HAp granules. The hollow HAp granules, containing the drug carriers on inner and outer surface, show the controlled drug release rate compared to the granules, containing the drug carriers only on the outer surface. The pores that are designed for insertion of drug carriers and also the preosteoblast. Consequently, they influenced on the cellular behavior; the first is that the cell proliferation and the second is that the early stage of osteogenic differentiation. The effects of controlled release rate is evident up through the two weeks after the cell seeding, results in increase of osteogenic differentiation. From the above results, the drug carriers loaded hollow HAp granules are shown to be patient-specific biomaterials and exhibit the potential for hard tissue regeneration.