Electrowetting on dielectric (EWOD), owing to its ability to electrically manipulate tiny individual droplets without involving movable mechanical parts, has received much attention in the past two decades [1, 2]. Despite tremendous promise, the use of solid dielectric layer between the aqueous droplet and underlying electrode is associated with inevitable physical and chemical heterogeneities [3, 4], leading to limited functionalities. For example, owing to the large contact angle (CA) hysteresis, contact line pinning  as well as CA saturation  at high voltage, it remains challenging to achieve reversible electrowetting with a large degree of switchability in ambient conditions. Moreover, activating droplet in EWOD is vulnerable to pronounced oscillation in response to an abrupt external stimulus, resulting in elongated time for the droplet to reach its equilibrium state . Here, we demonstrate a new paradigm of electrowetting on bio-inspired soft liquid-infused film (EWOLF) that allows for the enhanced reversibility and faster response time to reach the steady state simultaneously. The liquid-infused film is achieved by locking a liquid lubricant in a porous membrane through the delicate control of wetting properties of the liquid and solid phases. Taking advantage of the negligible contact line pinning at the liquid-liquid interface [8, 9], the droplet response in EWOLF can be electrically addressed with enhanced degree of switchability and reversibility compared to the conventional EWOD. Moreover, we show that the infiltration of liquid lubricant phase in the porous membrane also efficiently enhances the viscous energy dissipation, suppressing the droplet oscillation and leading to fast response without sacrificing the desired electrowetting reversibility. Meanwhile, we find that the enhanced damping effect associated with the EWOLF can be tailored by manipulating the viscosity and thickness of liquid lubricant. We also demonstrate the feasibility of developing adaptive liquid lens for fast focusing using the as-proposed EWOLF. References:  B. Berge, C. R. Acad. Sci. II 317, 157 (1993).  H. J. J. Verheijen and M. W. J. Prins, Langmuir 15, 6616 (1999).  G. Manukyan, J. M. Oh, D. van den Ende, R. G. H. Lammertink, and F. Mugele, Phys. Rev. Lett. 106, 014501 (2011).  G. McHale, C. V. Brown, M. I. Newton, G. G. Wells, and N. Sampara, Phys. Rev. Lett. 107, 186101 (2011).  X. M. Chen, R. Y. Ma, J. T. Li, C. L. Hao, W. Guo, B. L. Luk, S. C. Li, S. H. Yao, and Z. K. Wang, Phys. Rev. Lett. 109, 116101 (2012).  J. Liu, M. R. Wang, S. Chen, and M. O. Robbins, Phys. Rev. Lett. 108, 216101 (2012).  S. R. Annapragada, S. Dash, S. V. Garimella, and J. Y. Murthy, Langmuir 27, 8198 (2011).  A. Lafuma and D. Quï¿½rï¿½, EPL 96, 56001 (2011).  T. S. Wong, S. H. Kang, S. K. Y. Tang, E. J. Smythe, B. D. Hatton, A. Grinthal, and J. Aizenberg, Nature 477, 443 (2011).