Recently triboelectric nanogenerator (TENG) devices that transform environmental mechanical energy to electric power have been demonstrated as a renewable, clean and usable power source. In this talk, we will demonstrate several novel high-performance TENGs for implantable devices. First is a novel sandwich-shape triboelectric nanogenerator to convert low-frequency mechanical energy to electric energy with double frequency which can be directly used to drive an implantable 3-D microelectrode array for neural prosthesis without any energy storage unit or rectification circuit. Second is a hybrid NanoGenerator which has Micro/nanostructures on the PDMS surface for triboelectric generator and PVDF thin film as piezoelectric generator to enhance the output performance, the power density of this device can be reach to 50mW/cm3, and demonstrate the application in self-powering active implantable sensor. Third, a single-friction-surface triboelectric generator (STEG) has been developed and characterized as self-powered touch sensor could potentially be used to develop self-powered supersensitive artificial skin, etc.