New solutions are needed to reduce the weight of the machines that move people and goods on land, sea and air. The potential for reducing weight using high-strength steels, aluminum, titanium and magnesium alloys is well established. Key is to achieve the weight reduction economically. This requires optimization of the material properties and processes together with robust design tools and joining technologies to enable multi-material structures. Lightweight Innovations for Tomorrow (LIFT) was established to accelerate the adoption of advanced metals and serves as the bridge between basic research and final product commercialization. Our industry partners in collaboration with an extensive network of universities and the national and federal laboratories are developing the next generation of advanced manufacturing processes. This talk will provide on overview of the challenges and describe how new materials and processes, coupled with Integrated Computational Materials Engineering, are advancing the technology.